Ningbo Inno Pharmchem Co., Ltd is a TUV Rheiland ISO9001:2008 certificated company.Now N-(2-Bromoethyl)-1,3-propanediamine is available in our company. N-(2-Bromoethyl)-1,3-propanediamine(CAS NO.:23545-42-8) dihydrobromide is usually used as intermediate of amifostine. Amifostine was used to be the most effective drug of more than 4,000 kinds of radiation protection drugs that was synthesized by Walter-Reed Army Institute of Research during the Cold War, is also the first pan-cell protective agent that approved by U.S. FDA, that is, broad-spectrum selective cytoprotective agent. It can selectively protect normal organs from the chemotherapy, radiation toxicity attacks, rather than to protect tumor tissue. Therefore, it can significantly improve the patient chemotherapy, radiation tolerance, to improve their quality of life.
Uses For amifostine
Amifostine is used to help prevent or lessen some of the side effects on the kidneys and salivary glands that are caused by cisplatin (a cancer medicine) or radiation therapy.Amifostine is to be given only by or under the immediate supervision of your doctor.Once a medicine has been approved for marketing for a certain use, experience may show that it is also useful for other medical problems. Although this use is not included in the product labeling, amifostine is used in certain patients with the following medical conditions:
- Mucositis in patients receiving radiation therapy or radiation combined with chemotherapy
- Myelodysplastic syndromes
Proper Use of amifostine
A nurse or other trained health professional will give you amifostine in a hospital or cancer treatment center. amifostine is given through a needle placed in one of your veins.
amifostine is given before cisplatin therapy or radiation therapy. You may also receive other medicines to help prevent nausea and vomiting.
Drink plenty of fluids during the 24 hours before receiving amifostine.
Precautions While Using amifostine
It is very important that your doctor check your progress at regular visits to allow for changes in your dose. Blood tests may be needed to check for any unwanted effects.
Low blood pressure (hypotension) may occur with amifostine. Check with your doctor right away if you have the following symptoms: blurred vision; confusion; severe dizziness, faintness, or lightheadedness when getting up from a lying or sitting position suddenly; sweating; or unusual tiredness or weakness.
Serious skin reactions can occur with amifostine. Check with your doctor right away if you have a rash on the lips or mouth; red skin lesions on the palms of the hands or soles of the feet; sores or ulcers on the skin; or fever or chills while you are receiving amifostine.
amifostine may cause a serious type of allergic reaction called anaphylaxis. Anaphylaxis can be life-threatening and requires immediate medical attention. Call your doctor right away if you have a rash; itching; trouble breathing; any swelling of your hands, face, or mouth; or chest pain after you receive amifostine.
amifostine may cause nausea and/or vomiting in most people, sometimes even after receiving medicines to prevent it. Ask your doctor or nurse about other ways to control these side effects.
